6, 7 In this model, thrombi are formed and then embolized in repetitive cycles, prior to administration of antithrombotic drugs which abolish these cycles. 5 The Folts model is more clinically relevant as it encompasses the combined effects of deep‐vessel injury and high‐shear stress, thereby mimicking two key elements related to thrombus formation in atherosclerotic vessels. 3, 4 The time to cessation of blood flow can be affected by FeCl 3 concentration, types of anesthesia, as well as surgical techniques. Topical application of FeCl 3 on a vessel causes oxidative damage to and aggregation of red blood cells which mediate the adherence of platelets to the non‐denuded endothelium. 1 Accordingly, it is advocated that the model of thrombosis be carefully selected to answer the research question.
It has been reported that the same mice and same model in different laboratories have yielded different results, 1 which has been attributed to differences in the surgical techniques utilized rather than the models themselves. However, no single model can accurately recapitulate human vascular disease and therefore a range of different arterial thrombosis models have been developed. Animal models have led to the discovery of new strategies for cardiovascular protection and the prevention and management of thrombosis.
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